IFI44 Antibody: Functions, Research Applications, and Scientific Insights
Introduction
IFI44 (Interferon-Induced Protein 44) is an important protein involved in immune responses, particularly in antiviral defense mechanisms. It plays a crucial role in interferon signaling pathways and is implicated in autoimmune diseases, viral infections, and cancer research. IFI44 antibodies are widely used in immunological studies to investigate inflammatory processes and immune system regulation.
This article explores the characteristics, research applications, and clinical significance of IFI44 Antibody, incorporating references from government (.gov) and educational (.edu) sources to provide reliable scientific insights.
What is IFI44 Antibody?
IFI44 is an interferon-stimulated gene (ISG) that is strongly upregulated in response to viral infections and inflammatory stimuli. The IFI44 antibody is used to detect and analyze IFI44 protein expression in biological samples.
For an overview of interferon-stimulated genes like IFI44, visit NCBI’s Gene Database.
Product Specifications
- Host Species: Rabbit/Goat
- Target: IFI44 Protein
- Form: Polyclonal/Monoclonal
- Purity: Affinity-purified
- Buffer Composition: PBS, pH 7.4
- Preservative: 0.02% Sodium Azide
- Applications: Western Blotting, Immunohistochemistry (IHC), ELISA, Flow Cytometry
For technical specifications, refer to FDA’s antibody-based assay guidelines.
Key Research Applications
1. Immunology and Viral Infections
IFI44 is highly responsive to viral infections, particularly those involving RNA viruses like influenza and SARS-CoV-2. It serves as a biomarker for viral immunity studies.
For further information, visit Centers for Disease Control and Prevention (CDC).
2. Autoimmune Disease Research
Dysregulation of IFI44 expression has been linked to autoimmune diseases such as lupus and rheumatoid arthritis, making it an important target in immunological studies.
Find more at National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
3. Cancer Research
IFI44 plays a role in tumor immunology by regulating the immune response to cancer cells. It is being investigated as a potential biomarker in oncology research.
Explore research studies at National Cancer Institute (NCI).
Advantages of Using IFI44 Antibody
1. High Specificity and Sensitivity
IFI44 antibodies provide precise detection with minimal background interference.
2. Wide Range of Applications
Compatible with Western blotting, ELISA, IHC, and Flow Cytometry.
3. Reliable in Immunology, Autoimmune, and Cancer Research
IFI44’s role in multiple biological processes makes it a crucial target in various research fields.
For comparisons of commercial IFI44 antibodies, visit ABRF’s Antibody Validation Resource.
Storage and Handling Recommendations
- Store at -20°C or below for long-term stability.
- Avoid repeated freeze-thaw cycles to maintain antibody integrity.
- Prepare working dilutions fresh before use.
For best practices on antibody storage, visit National Center for Biotechnology Information (NCBI).
Alternative Products and Vendors
- Cell Signaling Technology (CST): Provides validated IFI44 antibodies for Western blotting.
- Abcam: Supplies a range of polyclonal and monoclonal IFI44 antibodies.
- Santa Cruz Biotechnology: Offers IFI44 antibodies suitable for IHC and ELISA.
For independent reviews, visit NIH’s Antibody Resource Guide.
Regulatory and Ethical Considerations
Before using antibodies in diagnostic applications, comply with regulatory standards outlined by the FDA and Office for Human Research Protections (OHRP).
Conclusion
IFI44 Polyclonal Antibody is an invaluable tool for researchers studying immunology, autoimmune diseases, and oncology. With its high specificity and versatile applications, it plays a crucial role in advancing scientific understanding of immune responses and disease mechanisms.
For additional information, refer to PubMed and Centers for Disease Control and Prevention (CDC) for peer-reviewed studies on IFI44-related research.