Testing machine learning techniques for general application by using protein secondary structure prediction. A brief survey with studies of pitfalls and benefits using a simple progressive learning approach
Many researchers have just lately used the prediction of protein secondary construction (native conformational states of amino acid residues) to check advances in predictive and machine studying know-how equivalent to Neural Web Deep Studying.
Protein secondary construction prediction continues to be a useful instrument in analysis in biomedicine and the life sciences, however it is usually extraordinarily attractive for testing predictive strategies equivalent to neural nets which are meant for various or extra normal functions. A complication is highlighted right here for researchers testing their strategies for different functions.
Trendy protein databases inevitably include necessary clues to the reply, so-called “sturdy buried clues”, although usually obscurely; they’re onerous to keep away from. It’s because most proteins or components of proteins in a contemporary protein knowledge base are associated to others by organic evolution.
For researchers creating machine studying and predictive strategies, this will overstate and so confuse understanding of the true high quality of a predictive technique. Nonetheless, for researchers utilizing the algorithms as instruments, understanding sturdy buried clues is of nice worth, as a result of they should make most use of all data obtainable.
A easy technique associated to the GOR strategies however with some options of neural nets within the sense of progressive studying of huge numbers of weights, is used to discover this. It may well purchase tens of hundreds of thousands and therefore gigabytes of weights, however they’re realized stably by exhaustive sampling. The importance of the findings is mentioned within the mild of promising latest outcomes from AlphaFold utilizing Google’s DeepMind.
Predicted Construction of Totally Activated Tas1R3/1R3′ Homodimer Certain to G Protein and Pure Sugars: Structural Insights into G Protein Activation by a Class C Candy Style Homodimer with Pure Sugars
The Tas1R3 G protein-coupled receptor constitutes the principle element of candy style sensory response in people through forming a heterodimer with Tas1R2 or a homodimer with Tas1R3. The Tas1R3/1R3′ homodimer serves as a low-affinity candy style receptor, stimulating gustducin G protein (GGust) signaling within the presence of a excessive focus of pure sugars.
This gives a further means to detect the style of pure sugars, thereby differentiating the flavors between pure sugars and synthetic sweeteners. We report right here the expected 3D construction of energetic state Tas1R3/1R3′ homodimer complexed with heterotrimeric GGust and sucrose.
We found that the GGust makes ionic anchors to intracellular loops 1 and a pair of of Tas1R3 whereas the Gα-α5 helix engages the cytoplasmic area extensively by way of salt bridge and hydrophobic interactions. We present that within the activation of this advanced the Venus flytrap domains of the homodimer bear a exceptional twist as much as ∼100° rotation across the vertical axis to undertake a closed-closed conformation whereas the intracellular area relaxes to an open-open conformation.
We discover that binding of sucrose to the homodimer stabilizes a preactivated conformation with a largely open intracellular area that recruits and prompts the GGust. Upon activation, the Gα subunit spontaneously opens up the nucleotide-binding web site, making nucleotide trade facile for signaling.
This activation of GGust promotes the interdomain twist of the Venus flytrap domains. These constructions and transformations may probably be a foundation for the design of latest sweeteners with larger exercise and fewer disagreeable flavors.
A novel lncRNA-protein interplay prediction technique based mostly on deep forest with cascade forest construction
Lengthy noncoding RNAs (lncRNAs) regulate many organic processes by interacting with corresponding RNA-binding proteins. The identification of lncRNA-protein Interactions (LPIs) is considerably necessary to properly characterize the organic features and mechanisms of lncRNAs. Present computational strategies have been successfully utilized to LPI prediction.
Nonetheless, the vast majority of them had been evaluated solely on one LPI dataset, thereby leading to prediction bias. Extra importantly, a part of fashions didn’t uncover doable LPIs for brand new lncRNAs (or proteins). As well as, the prediction efficiency stays restricted. To unravel with the above issues, on this research, we develop a Deep Forest-based LPI prediction technique (LPIDF).
First, 5 LPI datasets are obtained and the corresponding sequence data of lncRNAs and proteins are collected. Second, options of lncRNAs and proteins are constructed based mostly on four-nucleotide composition and BioSeq2vec with encoder-decoder construction, respectively.
Lastly, a deep forest mannequin with cascade forest construction is developed to seek out new LPIs. We evaluate LPIDF with 4 classical affiliation prediction fashions based mostly on three fivefold cross validations on lncRNAs, proteins, and LPIs.
LPIDF obtains higher common AUCs of 0.9012, 0.6937 and 0.9457, and the perfect common AUPRs of 0.9022, 0.6860, and 0.9382, respectively, for the three CVs, considerably outperforming different strategies. The outcomes present that the lncRNA FTX could work together with the protein P35637 and wishes additional validation.
Construction, Exercise and Perform of the MLL2 (KMT2B) Protein Lysine Methyltransferase
The Blended Lineage Leukemia 2 (MLL2) protein, also referred to as KMT2B, belongs to the household of mammalian histone H3 lysine 4 (H3K4) methyltransferases. It’s a giant protein of 2715 amino acids, broadly expressed in grownup human tissues and a paralog of the MLL1 protein.
MLL2 accommodates a attribute C-terminal SET area answerable for methyltransferase exercise and kinds a protein advanced with WRAD (WDR5, RbBP5, ASH2L and DPY30), host cell components half (HCF half) and Menin. The MLL2 advanced is answerable for H3K4 trimethylation (H3K4me3) on particular gene promoters and close by cis-regulatory websites, regulating bivalent developmental genes in addition to stem cell and germinal cell differentiation gene units.
Furthermore, MLL2 performs a important function in improvement and germ line deletions of Mll2 have been related to early progress retardation, neural tube defects and apoptosis that results in embryonic dying. It has additionally been concerned within the management of voluntary motion and the pathogenesis of early stage childhood dystonia.
Moreover, tumor-promoting features of MLL2 have been detected in a number of most cancers sorts, together with colorectal, hepatocellular, follicular most cancers and gliomas. On this evaluation, we talk about the principle structural and practical elements of the MLL2 methyltransferase with explicit emphasis on transcriptional mechanisms, gene regulation and affiliation with ailments.
Molecular hybrids: A five-year survey on constructions of a number of focused hybrids of protein kinase inhibitors for most cancers remedy
Protein kinases have grown over the previous few years as an important goal for various most cancers sorts. With the multifactorial nature of most cancers, and the quick improvement of drug resistance for standard chemotherapeutics, a method for designing multi-target brokers was advised to probably improve drug efficacy, reduce unwanted effects and retain the right pharmacokinetic properties.
Kinase inhibitors had been used extensively in such technique. Totally different kinase inhibitor brokers which goal EGFR, VEGFR, c-Met, CDK, PDK and different targets had been merged into hybrids with standard chemotherapeutics equivalent to tubulin polymerization and topoisomerase inhibitors. Different hybrids had been designed gathering kinase inhibitors with focused most cancers remedy equivalent to HDAC, PARP, HSP 90 inhibitors.
NPY Y2 Receptor-C/N Terminus |
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| RA14136 | Neuromics | 50 ul | EUR 315.6 |
Anti-CADM4 (C Terminus) antibody |
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| STJ71378 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-APOL4 (C Terminus) antibody |
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| STJ71652 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-MTMR9 (C Terminus) antibody |
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| STJ70067 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-FOXP2 (C terminus) antibody |
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| STJ70076 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-VPS45 (C Terminus) antibody |
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| STJ70451 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-OSBP1 (C Terminus) antibody |
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| STJ70454 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-VPS29 (C Terminus) antibody |
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| STJ70499 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-VDAC2 (C Terminus) antibody |
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| STJ70527 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-PCSK9 (C Terminus) antibody |
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| STJ70676 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-NANOG (C Terminus) antibody |
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| STJ71127 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-CACNB4 (C terminus) antibody |
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| STJ70634 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-ALDH1A1 (C Terminus) antibody |
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| STJ70020 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal ATG4C Antibody (C- terminus) |
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| APG02050G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human ATG4C (C- terminus). This antibody is tested and proven to work in the following applications: |
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Anti-Perilipin (C Terminus) antibody |
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| STJ71145 | St John's Laboratory | 100 µg | EUR 430.8 |
Protein Interacting With Carboxyl Terminus 1 (PICT1) Antibody |
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| abx430452-200ul | Abbexa | 200 ul | EUR 343.2 |
Anti-Nsg2 (mouse, C terminus) antibody |
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| STJ73459 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-SORL1 / LR11 (C Terminus) antibody |
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| STJ70018 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-CD20 / MS4A1 (C Terminus) antibody |
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| STJ70052 | St John's Laboratory | 100 µg | EUR 430.8 |
Carboxy Terminus of Hsp70-Interacting Protein (CHIP) Antibody |
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| 20-abx142251 | Abbexa |
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Anti-RNF31 / ZIBRA (C terminus) antibody |
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| STJ70235 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-SNX26 / TCGAP (C Terminus) antibody |
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| STJ70351 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal PTCH (C Terminus) Antibody (C-Term) |
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| APG00454G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PTCH (C Terminus) (C-Term). This antibody is tested and proven to work in the following applications: |
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Anti-NET1 / ARHGEF8 (C Terminus) antibody |
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| STJ70453 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal MTMR9 (C Terminus) Antibody (C-Term) |
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| APR17481G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human MTMR9 (C Terminus) (C-Term). This antibody is tested and proven to work in the following applications: |
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Polyclonal OLIG1 (C Terminus) Antibody (C-Term) |
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| AMM06890G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human OLIG1 (C Terminus) (C-Term). This antibody is tested and proven to work in the following applications: |
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Anti-SORBS1 / Ponsin (C Terminus) antibody |
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| STJ70187 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-P27KIP1 / CDKN1B (C Terminus) antibody |
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| STJ70026 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-ANILLIN / Scraps (C Terminus) antibody |
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| STJ70428 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-CIAS1 / cryopyrin ( C Terminus) antibody |
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| STJ70287 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-RNF213 / C17orf27 (C Terminus) antibody |
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| STJ71093 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-LRRK2 / PARK8 (near C Terminus) antibody |
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| STJ70619 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-Munc13-4 / UNC13D (C terminus) antibody |
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| STJ70556 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-SLC7A6 / y+LAT-2 (C Terminus) antibody |
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| STJ73535 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-SMO (C Terminus) Antibody |
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| APR12177G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SMO (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-Cone-rod homeobox (C Terminus) antibody |
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| STJ73027 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-EXOG Antibody (C Terminus) |
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| AMM04972G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-EXOG (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-JAK2 Antibody (C Terminus) |
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| APG00942G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-JAK2 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CD96 Antibody (C Terminus) |
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| APG00956G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD96 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Anti-GRB7 (N Terminus) antibody |
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| STJ70165 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-TFEB (N Terminus) antibody |
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| STJ70169 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-BAG5 (N Terminus) antibody |
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| STJ70196 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-PAX8 (N Terminus) antibody |
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| STJ70206 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-COMT (N Terminus) antibody |
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| STJ70636 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-ASIC1 Antibody (C Terminus) |
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| APR12075G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-ASIC1 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-Stap2 Antibody (C Terminus) |
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| APR16402G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Stap2 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-VPS29 (C Terminus) Antibody |
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| APR16424G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-VPS29 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-VPS45 (C Terminus) Antibody |
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| APR16427G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-VPS45 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-AIFM1 Antibody (C Terminus) |
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| AMM04875G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-AIFM1 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-APOA1 Antibody (C Terminus) |
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| AMM04883G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-APOA1 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-OSBP1 (C Terminus) Antibody |
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| AMM05066G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-OSBP1 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-PCSK9 (C Terminus) Antibody |
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| AMM05077G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-PCSK9 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-VDAC2 (C Terminus) Antibody |
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| AMM05155G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-VDAC2 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-SOX11 Antibody (C Terminus) |
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| APG00948G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SOX11 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-FCRL1 Antibody (C Terminus) |
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| APG00972G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-FCRL1 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CADM4 (C Terminus) Antibody |
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| APG00054G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CADM4 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-NANOG (C Terminus) Antibody |
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| APG00211G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-NANOG (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-GAPDH (C Terminus) Loading Control antibody |
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| STJ70553 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal CIAS1 / cryopyrin ( C Terminus) Antibody (C-Term) |
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| APG00389G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CIAS1 / cryopyrin ( C Terminus) (C-Term). This antibody is tested and proven to work in the following applications: |
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Anti-APOL6 (N Terminus) antibody |
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| STJ71653 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-LASP1 (N Terminus) antibody |
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| STJ70092 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-IRAK4 (N Terminus) antibody |
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| STJ70645 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-CACNB4 (C terminus) Antibody |
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| APR16230G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CACNB4 (C terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-ALDH1A1 (C Terminus) Antibody |
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| APG00021G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-ALDH1A1 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-CD20 / MS4A1 (C Terminus), biotinylated antibody |
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| STJ73273 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-IFITM3 (N terminus) antibody |
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| STJ73252 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-CD2BP2 (N Terminus) antibody |
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| STJ70564 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-Vimentin Antibody (C Terminus) |
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| APG00970G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Vimentin (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-Perilipin (C Terminus) Antibody |
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| AMM05081G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Perilipin (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-RNF34 / RFI (N Terminus) antibody |
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| STJ70337 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-SORL1 / LR11 (C Terminus) Antibody |
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| APR12179G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SORL1 / LR11 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CXCR7 / RDC1 Antibody (C Terminus) |
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| APR16258G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CXCR7 / RDC1 (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CD20 / MS4A1 (C Terminus) Antibody |
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| APG00066G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD20 / MS4A1 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-SNX26 / TCGAP (C Terminus) Antibody |
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| APR16393G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SNX26 / TCGAP (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-RNF31 / ZIBRA (C terminus) Antibody |
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| APG00282G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-RNF31 / ZIBRA (C terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CLEC12A / MICL Antibody (C Terminus) |
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| APR16237G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CLEC12A / MICL (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-NET1 / ARHGEF8 (C Terminus) Antibody |
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| APG00216G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-NET1 / ARHGEF8 (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-Fgf14 (mouse N terminus) antibody |
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| STJ72909 | St John's Laboratory | 100 µg | EUR 430.8 |
Anti-SNX26 / TCGAP (N Terminus) antibody |
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| STJ70984 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-SORBS1 / Ponsin (C Terminus) Antibody |
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| APR16399G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SORBS1 / Ponsin (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-ANILLIN / Scraps (C Terminus) Antibody |
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| APG00026G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-ANILLIN / Scraps (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-P27KIP1 / CDKN1B (C Terminus) Antibody |
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| APG00230G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-P27KIP1 / CDKN1B (C Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-SCARB1 / SR-BI Antibody (C Terminus) |
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| AMM05110G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SCARB1 / SR-BI (C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-LRRK2 / PARK8 (near C Terminus) Antibody |
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| APR12148G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-LRRK2 / PARK8 (near C Terminus) . This antibody is tested and proven to work in the following applications: |
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Anti-GAPDH (C Terminus) Loading Control, biotinylated antibody |
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| STJ73275 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-Munc13-4 / UNC13D (C terminus) Antibody |
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| APG00205G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-Munc13-4 / UNC13D (C terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal BAG5 (N Terminus) Antibody (N-Term) |
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| APG02187G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human BAG5 (N Terminus) (N-Term). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-GAPDH (C Terminus) Loading Control Antibody |
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| AMM04988G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GAPDH (C Terminus) Loading Control . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-PAX8 (N Terminus) Antibody |
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| APR12161G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-PAX8 (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-GRB7 (N Terminus) Antibody |
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| APR16287G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-GRB7 (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-NNMT Antibody (N Terminus) |
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| AMM05057G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-NNMT (N Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-COMT (N Terminus) Antibody |
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| AMRa00033G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-COMT (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-LASP1 (N Terminus) Antibody |
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| APR16321G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-LASP1 (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-NRARP Antibody (N Terminus) |
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| AMM05947G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-NRARP (N Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-IRAK4 (N Terminus) Antibody |
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| APG00171G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-IRAK4 (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CD2BP2 (N Terminus) Antibody |
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| APG00068G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD2BP2 (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal CHIT1 (aa409-423) Antibody (internal region, near C Terminus) |
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| APG00787G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human CHIT1 (aa409-423) (internal region, near C Terminus). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-CD47 Antibody (internal region (near C terminus)) |
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| APG00949G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CD47 (internal region (near C terminus)). This antibody is tested and proven to work in the following applications: |
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Anti-NEDD8 conjugating enzyme (N Terminus) antibody |
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| STJ72552 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Fgf14 (mouse N terminus) Antibody (N-Term) |
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| APR11926G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Fgf14 (mouse N terminus) (N-Term). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-RNF34 / RFI (N Terminus) Antibody |
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| APG00283G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-RNF34 / RFI (N Terminus) . This antibody is tested and proven to work in the following applications: |
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DnaK (HSP70) E.Coli Recombinant Protein |
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| PROTP0A6Y8 | BosterBio | Regular: 50ug | EUR 380.4 |
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Description: Recombinant Dnak produced in E.Coli is a single, non-glycosylated polypeptide chain containing 638 amino acids and having a molecular mass of 69 kDa. |
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Polyclonal Goat Anti-COL4A4 Antibody (internal region (near C terminus)) |
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| APG00945G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-COL4A4 (internal region (near C terminus)). This antibody is tested and proven to work in the following applications: |
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Anti-Aspartyl-tRNA Synthetase (N terminus) antibody |
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| STJ73458 | St John's Laboratory | 100 µg | EUR 430.8 |
Polyclonal Goat Anti-SNX26 / TCGAP (N Terminus) Antibody |
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| APR16394G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SNX26 / TCGAP (N Terminus) . This antibody is tested and proven to work in the following applications: |
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Polyclonal Cone-rod homeobox (C Terminus) Antibody (internal region, near C-Term) |
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| APR11631G | Leading Biology | 0.1 mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Cone-rod homeobox (C Terminus) (internal region, near C-Term). This antibody is tested and proven to work in the following applications: |
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Polyclonal Goat Anti-ORL1 / LOX1 / LOXIN Antibody (N Terminus) |
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| AMM05063G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-ORL1 / LOX1 / LOXIN (N Terminus). This antibody is tested and proven to work in the following applications: |
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Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-100ug |
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| QP7629-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-200ug |
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| QP7629-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-500ug |
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| QP7629-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-10ug |
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| QP7629-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-50ug |
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| QP7629-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant E.coli Chaperone protein DnaK Protein, His, E.coli-1mg |
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| QP7629-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Polyclonal NEDD8 conjugating enzyme (N Terminus) Antibody (N-Term) |
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| APG00755G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human NEDD8 conjugating enzyme (N Terminus) (N-Term). This antibody is tested and proven to work in the following applications: |
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Escherichia coli Chaperone protein DnaK (dnaK) |
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| 1-CSB-YP633459EGW | Cusabio |
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Description: Recombinant Escherichia coli Chaperone protein DnaK(dnaK) expressed in Yeast |
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Escherichia coli Chaperone protein DnaK (dnaK) |
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| 1-CSB-EP633459EGW | Cusabio |
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Description: Recombinant Escherichia coli Chaperone protein DnaK(dnaK) expressed in E.coli |
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Polyclonal Goat Anti-CXCR1 Antibody (internal region (near N terminus)) |
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| APG00950G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CXCR1 (internal region (near N terminus)). This antibody is tested and proven to work in the following applications: |
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Recombinant Human DnaK Protein, His, E.coli-10ug |
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| QP11683-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant Human DnaK Protein, His, E.coli-50ug |
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| QP11683-50ug | EnQuireBio | 50ug | EUR 241.2 |
Recombinant Human DnaK Protein, His, E.coli-1mg |
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| QP11683-1mg | EnQuireBio | 1mg | EUR 2350.8 |
Polyclonal Goat Anti-CX3CR1 Antibody (internal region (near N terminus)) |
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| APG00965G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-CX3CR1 (internal region (near N terminus)). This antibody is tested and proven to work in the following applications: |
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Recombinant other DnaK Protein, Untagged, E.coli-10ug |
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| QP11682-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant other DnaK Protein, Untagged, E.coli-50ug |
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| QP11682-50ug | EnQuireBio | 50ug | EUR 241.2 |
Recombinant other DnaK Protein, Untagged, E.coli-1mg |
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| QP11682-1mg | EnQuireBio | 1mg | EUR 2230.8 |
Polyclonal Goat Anti-NFATC3 / NFAT4 Antibody (internal region (near N Terminus)) |
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| APR16331G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-NFATC3 / NFAT4 (internal region (near N Terminus)). This antibody is tested and proven to work in the following applications: |
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Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-100ug |
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| QP8868-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-200ug |
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| QP8868-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-500ug |
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| QP8868-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-1mg |
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| QP8868-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-10ug |
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| QP8868-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant E.coli Transcription termination factor Rho Protein, His, E.coli-50ug |
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| QP8868-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant other DnaK ATPase-BD Protein, Untagged, E.coli-10ug |
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| QP11684-10ug | EnQuireBio | 10ug | EUR 186 |
Recombinant other DnaK ATPase-BD Protein, Untagged, E.coli-50ug |
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| QP11684-50ug | EnQuireBio | 50ug | EUR 241.2 |
Recombinant E.Coli Dnak (HSP70) |
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| 7-06943 | CHI Scientific | 10µg | Ask for price |
Recombinant E.Coli Dnak (HSP70) |
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| 7-06944 | CHI Scientific | 50µg | Ask for price |
Recombinant E.Coli Dnak (HSP70) |
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| 7-06945 | CHI Scientific | 1mg | Ask for price |
Recombinant E.Coli Dnak (HSP70) |
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| RP-615 | Alpha Diagnostics | 20 ug | EUR 196.8 |
Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-100ug |
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| QP6942-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-200ug |
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| QP6942-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-500ug |
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| QP6942-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-10ug |
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| QP6942-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-50ug |
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| QP6942-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant other DnaK ATPase-BD Protein, Untagged, E.coli-1mg |
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| QP11684-1mg | EnQuireBio | 1mg | EUR 2230.8 |
Chaperone Protein DnaK (DNAK) Antibody |
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| 20-abx300649 | Abbexa |
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Recombinant Mycoplasma Chaperone protein DnaK Protein, His-SUMO, E.coli-1mg |
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| QP6942-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Dnak protein |
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| 30R-1019 | Fitzgerald | 100 ug | EUR 268.8 |
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Description: Purified recombinant E.coli Dnak protein |
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Dnak protein |
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| 30R-1020 | Fitzgerald | 100 ug | EUR 268.8 |
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Description: Purified recombinant E.coli Dnak protein |
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Dnak protein |
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| 30R-1021 | Fitzgerald | 100 ug | EUR 268.8 |
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Description: Purified recombinant E.coli Dnak protein |
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Dnak protein |
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| 30R-1022 | Fitzgerald | 100 ug | EUR 268.8 |
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Description: Purified recombinant E.coli Dnak protein |
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Dnak protein |
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| 30R-1023 | Fitzgerald | 100 ug | EUR 268.8 |
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Description: Purified recombinant E.coli Dnak protein |
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Nitric oxide donor molecules had been additionally merged with kinase inhibitors for most cancers remedy. The present evaluation presents the hybrids designed prior to now 5 years discussing their design rules, outcomes and highlights their future views.
