Crystal structure of a MarR family protein from the psychrophilic bacterium Paenisporosarcina sp. TG-14 in complex with a lipid-like molecule
MarR household proteins regulate the transcription of a number of antibiotic-resistance genes and are broadly present in micro organism and archaea. Lately, a brand new MarR household gene was recognized by genome evaluation of the psychrophilic bacterium Paenisporosarcina sp.
TG-14, which was remoted from sediment-laden basal ice in Antarctica. On this research, the crystal construction of the MarR protein from Paenisporosarcina sp. TG-14 (PaMarR) was decided at 1.6 Å decision. Within the crystal construction, a novel lipid-type compound (palmitic acid) was present in a deep cavity, which was assumed to be an effector-binding web site.
Comparative structural evaluation of homologous MarR household proteins from a mesophile and a hyperthermophile confirmed that the DNA-binding area of PaMarR exhibited comparatively excessive mobility, with a disordered area between the β1 and β2 strands.
As well as, structural comparability with different homologous advanced constructions means that this construction constitutes a conformer reworked by palmitic acid. Biochemical evaluation additionally demonstrated that PaMarR binds to cognate DNA, the place PaMarR is understood to acknowledge two putative binding websites relying on its molar focus, indicating that PaMarR binds to its cognate DNA in a stoichiometric method.
The current research offers structural data on the cold-adaptive MarR protein with an aliphatic compound as its putative effector, extending the scope of MarR household protein analysis.
AlphaFold 2: Why It Works and Its Implications for Understanding the Relationships of Protein Sequence, Construction, and Operate
AlphaFold 2 (AF2) was the star of CASP14, the final biannual construction prediction experiment. Utilizing novel deep studying, AF2 predicted the constructions of many troublesome protein targets at or close to experimental decision. Right here, we current our perspective of why AF2 works and present that it’s a very refined fold recognition algorithm that exploits the completeness of the library of single area PDB constructions.
It has additionally realized native aspect chain packing rearrangements that allow it to refine proteins to excessive decision. The advantages and limitations of its potential to foretell the constructions of many extra proteins at or near atomic element are mentioned.
Forces concerned in freeze-induced egg yolk gelation: Results of assorted bond dissociation reagents on gel properties and protein construction adjustments
Urea, sodium dodecyl sulfate (SDS) and β-mercaptoethanol (2-ME) had been used to observe the roles of hydrogen bonds, hydrophobic interactions and disulfide bonds in frozen egg yolk. Yolk samples had been ready with a denaturant, and the textural traits, turbidity properties, protein patterns and constructions had been analysed.
The outcomes confirmed that SDS or 2-ME addition to egg yolk promoted its turbidity and texture properties, however urea modified the turbidity in another way. SDS-PAGE outcomes confirmed that yolk protein patterns with urea barely diminished the quantity of excessive molecular weight substances, whereas SDS and 2-ME addition elevated the quantity.
ATR-FTIR spectroscopy revealed that the protein secondary constructions modified from ordered constructions to random coils. The feel properties had been correlated with the protein secondary construction, particularly β-sheets and β-turns. Thus, the three bond dissociation reagents induced protein denaturation. Hydrogen bonds had been the vital power affecting frozen egg yolk gelation, adopted by hydrophobic interactions and disulfide bonds.
The First Cytoplasmic Loop within the Core Construction of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Accommodates A number of Amino Acids Important for Its Expression
ABCC1 (human multidrug resistance protein 1 (hMRP1)) is an ATP-binding cassette transporter which effluxes xeno- and endobiotic natural anions and confers multidrug resistance by means of energetic drug efflux. The 17 transmembrane α-helices of hMRP1 are distributed amongst three membrane spanning domains (MSD0, 1, 2) with MSD1,2 every adopted by a nucleotide binding area to type the 4-domain core construction.
Eight conserved residues within the first cytoplasmic loop (CL4) of MSD1 within the descending α-helix (Gly392, Tyr404, Arg405), the perpendicular coupling helix (Asn412, Arg415, Lys416), and the ascending α-helix (Glu422, Phe434) had been focused for mutagenesis.
Mutants with each alanine and identical cost substitutions of the coupling helix residues had been expressed in HEK cells at wild-type hMRP1 ranges and their transport exercise was solely reasonably compromised. In distinction, mutants of the flanking amino acids (G392I, Y404A, R405A/Ok, E422A/D, and F434Y) had been very poorly expressed though Y404F, E422D, and F434A had been readily expressed and transport competent.
Modeling analyses indicated that Glu422 and Arg615 may type an ion pair that may stabilize transporter expression. Nevertheless, this was not supported by change mutations E422R/R615E which did not enhance hMRP1 ranges. Further constructions accompanied by rigorous biochemical validations are wanted to higher perceive the bonding interactions essential for steady hMRP1 expression.
Construction dictates the mechanism of ligand recognition within the histidine and maltose binding proteins
Two mechanisms, induced match (IF) and conformational choice (CS), have been proposed to elucidate ligand recognition coupled conformational adjustments. The histidine binding protein (HisJ) adopts the CS mechanism, through which a pre-equilibrium is established between the open and the closed states with the ligand binding to the closed state.
Regardless of being structurally just like HisJ, the maltose binding protein (MBP) adopts the IF mechanism, through which the ligand binds the open state and induces a transition to the closed state. To know the molecular determinants of this distinction, we carried out molecular dynamics (MD) simulations of coarse-grained twin construction based mostly fashions.
We discover that intra-protein contacts distinctive to the closed state are ample to advertise the conformational transition in HisJ, indicating a CS-like mechanism. In distinction, further ligand-mimicking contacts are required to “induce” the conformational transition in MBP suggesting an IF-like mechanism.
In settlement with experiments, destabilizing modifications to 2 structural options, the backbone helix (SH) and the balancing interface (BI), current in MBP however absent in HisJ, scale back the necessity for ligand-mimicking contacts indicating that SH and BI act as structural restraints that maintain MBP within the open state.
We introduce an SH like ingredient into HisJ and observe that this will impede the conformational transition rising the significance of ligand-mimicking contacts. Equally, simultaneous mutations to BI and SH in MBP scale back the barrier to conformational transitions considerably and promote a CS-like mechanism.
Recombinant Mouse MARCO Protein (N-His) |
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| MBS2557470-5x005mg | MyBiosource | 5x0.05mg | EUR 1265 |
Recombinant Mouse MARCO Protein (His Tag) |
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| PKSM041305-10ug | Elabscience Biotech | 10ug | EUR 98 |
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Description: Mouse |
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Recombinant Mouse MARCO Protein (His Tag) |
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| PKSM041305-50ug | Elabscience Biotech | 50ug | EUR 262 |
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Description: Mouse |
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Recombinant Mouse MARCO protein (N-8His) |
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| CD00311-10ug | Jiaxing Korain Biotech Ltd (BT Labs) | 10ug | EUR 188 |
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Description: Recombinant Mouse Macrophage Receptor MARCO is produced by our Mammalian expression system and the target gene encoding Gln70-Ser518 is expressed with a 8His tag at the N-terminus. |
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Recombinant Mouse MARCO protein (N-8His) |
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| CD00311-50ug | Jiaxing Korain Biotech Ltd (BT Labs) | 50ug | EUR 517 |
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Description: Recombinant Mouse Macrophage Receptor MARCO is produced by our Mammalian expression system and the target gene encoding Gln70-Ser518 is expressed with a 8His tag at the N-terminus. |
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MARCO Protein, Mouse, Recombinant (His Tag) |
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| E45M52845M1-100 | EnoGene | 100 ug | EUR 1046.77 |
MARCO Protein, Mouse, Recombinant (His Tag) |
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| MBS8122662-01mg | MyBiosource | 0.1mg | EUR 395 |
MARCO Protein, Mouse, Recombinant (His Tag) |
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| MBS8122662-5x01mg | MyBiosource | 5x0.1mg | EUR 1635 |
Recombinant Mouse Marco Protein, His (Fc)-Avi-tagged |
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| Marco-5371M | Creative BioMart | 50ug | EUR 2398.4 |
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Description: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
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Recombinant Mouse Macrophage receptor MARCO (Marco), partial |
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| MBS1473644-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1380 |
Recombinant Mouse Macrophage receptor MARCO (Marco), partial |
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| MBS1473644-005mgMammalianCell | MyBiosource | 0.05mg(Mammalian-Cell) | EUR 1635 |
Recombinant Mouse Macrophage receptor MARCO (Marco), partial |
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| MBS1473644-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1380 |
Recombinant Mouse Macrophage receptor MARCO (Marco), partial |
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| MBS1473644-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1635 |
Recombinant Mouse Macrophage receptor MARCO (Marco), partial |
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| MBS1473644-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2190 |
Recombinant Human MARCO Protein |
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| RP02733 | Abclonal | 100μg | EUR 258.6 |
Recombinant Mouse Macrophage Receptor MARCO/MARCO (N-8His) |
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| CU63-10ug | Novoprotein | 10ug | EUR 157.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Macrophage Receptor MARCO/MARCO (N-8His) |
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| CU63-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Macrophage Receptor MARCO/MARCO (N-8His) |
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| CU63-500ug | Novoprotein | 500ug | EUR 1399.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Macrophage Receptor MARCO/MARCO (N-8His) |
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| CU63-50ug | Novoprotein | 50ug | EUR 327.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Macrophage Receptor MARCO/MARCO (N-8His) |
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| AP76480 | SAB | 1mg | EUR 2369 |
MARCO Recombinant Protein (Rat) |
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| RP210899 | ABM | 100 ug | Ask for price |
MARCO Recombinant Protein (Human) |
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| RP018841 | ABM | 100 ug | Ask for price |
Recombinant Human MARCO Protein, N-His-SUMO |
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| MBS1564913-01mg | MyBiosource | 0.1mg | EUR 385 |
OPCD00816-10UG - MARCO Recombinant Protein |
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| OPCD00816-10UG | Aviva Systems Biology | 10ug | EUR 119 |
OPCD00816-50UG - MARCO Recombinant Protein |
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| OPCD00816-50UG | Aviva Systems Biology | 50ug | EUR 299 |
OPCD00817-10UG - MARCO Recombinant Protein |
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| OPCD00817-10UG | Aviva Systems Biology | 10ug | EUR 129 |
OPCD00817-50UG - MARCO Recombinant Protein |
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| OPCD00817-50UG | Aviva Systems Biology | 50ug | EUR 309 |
OPCD00816-200UG - MARCO Recombinant Protein |
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| OPCD00816-200UG | Aviva Systems Biology | 200ug | EUR 589 |
OPCD00817-200UG - MARCO Recombinant Protein |
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| OPCD00817-200UG | Aviva Systems Biology | 200ug | EUR 619 |
Mouse MARCO Protein, His Tag |
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| E40MOP1250 | EnoGene | 20ug | EUR 495 |
Mouse MARCO Protein, His Tag |
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| MAR-M5245 | ACROBIOSYSTEMS | 100ug | EUR 2801.3 |
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Description: Mouse MARCO, His Tag (MAR-M5245) is expressed from human 293 cells (HEK293). It contains AA Gln 70 - Ser 518 (Accession # Q60754-1). |
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Recombinant Human Macrophage receptor MARCO (MARCO), partial |
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| MBS1395818-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1390 |
Recombinant Human Macrophage receptor MARCO (MARCO), partial |
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| MBS1395818-005mgMammalianCell | MyBiosource | 0.05mg(Mammalian-Cell) | EUR 1645 |
Recombinant Human Macrophage receptor MARCO (MARCO), partial |
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| MBS1395818-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1390 |
Recombinant Human Macrophage receptor MARCO (MARCO), partial |
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| MBS1395818-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1645 |
Recombinant Human Macrophage receptor MARCO (MARCO), partial |
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| MBS1395818-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2205 |
MARCO Protein Vector (Mouse) (pPM-C-HA) |
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| PV199316 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Mouse) (pPB-C-His) |
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| PV199314 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Mouse) (pPB-N-His) |
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| PV199315 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Mouse) (pPM-C-His) |
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| PV199317 | ABM | 500 ng | EUR 723.6 |
Recombinant Mesocricetus auratus Macrophage receptor MARCO (MARCO), partial |
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| MBS1306658-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1335 |
Recombinant Mesocricetus auratus Macrophage receptor MARCO (MARCO), partial |
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| MBS1306658-005mgMammalianCell | MyBiosource | 0.05mg(Mammalian-Cell) | EUR 1590 |
Recombinant Mesocricetus auratus Macrophage receptor MARCO (MARCO), partial |
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| MBS1306658-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1335 |
Recombinant Mesocricetus auratus Macrophage receptor MARCO (MARCO), partial |
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| MBS1306658-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1590 |
Recombinant Mesocricetus auratus Macrophage receptor MARCO (MARCO), partial |
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| MBS1306658-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2150 |
MARCO Recombinant Rabbit mAb |
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| BS45989 | Bioworld Biotech | 50 ul | EUR 398 |
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Description: Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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Mouse Marco / Macrophage receptor MARCO ELISA Kit |
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| E9673m | EIAab | 96T | EUR 776 |
Mouse Macrophage Receptor With Collagenous Structure (MARCO) Protein |
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| abx650074-100g | Abbexa | 100 µg | EUR 512.5 |
Mouse Macrophage Receptor With Collagenous Structure (MARCO) Protein |
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| 20-abx650074 | Abbexa |
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Mouse Macrophage Receptor With Collagenous Structure (MARCO) Protein |
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| abx650074-10g | Abbexa | 10 µg | EUR 212.5 |
Mouse Macrophage Receptor With Collagenous Structure (MARCO) Protein |
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| abx650074-50g | Abbexa | 50 µg | EUR 362.5 |
Mouse Macrophage Receptor MARCO (MARCO) ELISA Kit |
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| abx389793-96tests | Abbexa | 96 tests | EUR 687.5 |
Mouse Macrophage receptor MARCO, Marco ELISA KIT |
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| ELI-16328m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Macrophage Receptor MARCO (MARCO) ELISA Kit |
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| MBS9345146-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Macrophage Receptor MARCO (MARCO) ELISA Kit |
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| MBS9345146-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Macrophage Receptor MARCO (MARCO) ELISA Kit |
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| MBS9345146-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Macrophage Receptor MARCO (MARCO) ELISA Kit |
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| MBS9345146-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Mouse Macrophage receptor MARCO (MARCO) ELISA Kit |
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| RK13444 | Abclonal | 96T | EUR 322.37 |
Recombinant Human MARCO, His-tagged |
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| MARCO-750H | Creative BioMart | 25ug | EUR 255.2 |
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Description: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
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Mouse MARCO siRNA |
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| 20-abx923573 | Abbexa |
|
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Mouse MARCO Antibody |
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| GWB-D42395 | GenWay Biotech | 0.025 mg | Ask for price |
Mouse MARCO Antibody |
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| GWB-Q01556 | GenWay Biotech | 0.25 mg | Ask for price |
MARCO siRNA (Mouse) |
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| MBS8212597-15nmol | MyBiosource | 15nmol | EUR 405 |
MARCO siRNA (Mouse) |
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| MBS8212597-30nmol | MyBiosource | 30nmol | EUR 565 |
MARCO siRNA (Mouse) |
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| MBS8212597-5x30nmol | MyBiosource | 5x30nmol | EUR 2450 |
Human MARCO Protein Lysate |
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| MBS8414979-002mg | MyBiosource | 0.02mg | EUR 365 |
Human MARCO Protein Lysate |
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| MBS8414979-5x002mg | MyBiosource | 5x0.02mg | EUR 1410 |
Marco ELISA Kit| Mouse Macrophage receptor MARCO ELISA Kit |
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| EF015428 | Lifescience Market | 96 Tests | EUR 826.8 |
RAT ANTI MOUSE MARCO |
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| MBS215278-025mg | MyBiosource | 0.25mg | EUR 550 |
RAT ANTI MOUSE MARCO |
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| MBS215278-5x025mg | MyBiosource | 5x0.25mg | EUR 2295 |
RAT ANTI MOUSE MARCO |
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| MBS215282-0025mg | MyBiosource | 0.025mg | EUR 225 |
RAT ANTI MOUSE MARCO |
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| MBS215282-5x0025mg | MyBiosource | 5x0.025mg | EUR 835 |
Mouse MARCO Antibody (RPE) |
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| GWB-Q01559 | GenWay Biotech | 100 TESTS | Ask for price |
Human MARCO Protein, His Tag |
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| MAR-H5243 | ACROBIOSYSTEMS | 100ug | EUR 2801.3 |
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Description: Human MARCO, His Tag (MAR-H5243) is expressed from human 293 cells (HEK293). It contains AA Met 79 - Val 520 (Accession # Q9UEW3-1). |
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Mouse MARCO shRNA Plasmid |
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| 20-abx971431 | Abbexa |
|
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Mouse MARCO Antibody (FITC) |
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| GWB-3E5FC1 | GenWay Biotech | 0.05 mg | Ask for price |
Human MARCO Protein Lysate 20ug |
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| IHUMARCOPLLY20UG | Innovative research | each | EUR 213 |
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Description: Human MARCO Protein Lysate 20ug |
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Cynomolgus MARCO Protein, His Tag |
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| MAR-C5248 | ACROBIOSYSTEMS | 100ug | EUR 2801.3 |
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Description: Cynomolgus MARCO, His Tag (MAR-C5248) is expressed from human 293 cells (HEK293). It contains AA Met 79 - Ile 520 (Accession # A0A2K5X0Z2-1). |
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OCOA11954-20UG - MARCO Protein Lysate |
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| OCOA11954-20UG | Aviva Systems Biology | 20ug | EUR 169 |
Marco (untagged) - Mouse macrophage receptor with collagenous structure (Marco), (10ug) |
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| MC217282 | Origene Technologies GmbH | 10 µg | Ask for price |
Marc2 (NM_133684) Mouse Recombinant Protein |
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| E45M47149M5 | EnoGene | 20 ug | EUR 1924.54 |
Marc1 (NM_001081361) Mouse Recombinant Protein |
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| E45M42299E1 | EnoGene | 50 ug | EUR 528.13 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033487-001mg | MyBiosource | 0.01mg | EUR 160 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033487-005mg | MyBiosource | 0.05mg | EUR 280 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033487-01mg | MyBiosource | 0.1mg | EUR 405 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033487-02mg | MyBiosource | 0.2mg | EUR 490 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033487-05mg | MyBiosource | 0.5mg | EUR 930 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033083-001mg | MyBiosource | 0.01mg | EUR 165 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033083-005mg | MyBiosource | 0.05mg | EUR 285 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033083-01mg | MyBiosource | 0.1mg | EUR 425 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033083-02mg | MyBiosource | 0.2mg | EUR 515 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| MBS2033083-05mg | MyBiosource | 0.5mg | EUR 980 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPC614Mu01 | Cloud-Clone | 10ug | EUR 152 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| 4-RPC614Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Macrophage Receptor With Collagenous Structure expressed in: E.coli |
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Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPC614Ra01 | Cloud-Clone | 10ug | EUR 160 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| 4-RPC614Ra01 | Cloud-Clone |
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Description: Recombinant Rat Macrophage Receptor With Collagenous Structure expressed in: E.coli |
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Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51188-100ug | Biomatik Corporation | 100ug | EUR 468.6 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51188-1mg | Biomatik Corporation | 1mg | EUR 2074.8 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51188-50ug | Biomatik Corporation | 50ug | EUR 376.2 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51565-100ug | Biomatik Corporation | 100ug | EUR 492.8 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51565-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant Macrophage Receptor With Collagenous Structure (MARCO) |
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| RPU51565-50ug | Biomatik Corporation | 50ug | EUR 396 |
Marco (GFP-tagged) - Mouse macrophage receptor with collagenous structure (Marco), (10ug) |
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| MG222739 | Origene Technologies GmbH | 10 µg | Ask for price |
Marco (Myc-DDK-tagged) - Mouse macrophage receptor with collagenous structure (Marco) |
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| MR222739 | Origene Technologies GmbH | 10 µg | Ask for price |
Marco ORF Vector (Mouse) (pORF) |
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| ORF049829 | ABM | 1.0 ug DNA | EUR 607.2 |
MARCO Protein Vector (Rat) (pPM-C-HA) |
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| PV281204 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Rat) (pPB-C-His) |
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| PV281202 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Rat) (pPB-N-His) |
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| PV281203 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Rat) (pPM-C-His) |
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| PV281205 | ABM | 500 ng | EUR 723.6 |
MARCO Protein Vector (Human) (pPM-C-HA) |
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| PV025123 | ABM | 500 ng | EUR 394.8 |
Mouse MARCO HEK293 Overexpression Lysate |
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| MBS8116513-03mg | MyBiosource | 0.3mg | EUR 280 |
Mouse MARCO HEK293 Overexpression Lysate |
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| MBS8116513-5x03mg | MyBiosource | 5x0.3mg | EUR 1205 |
MARCO Protein Vector (Human) (pPB-C-His) |
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| PV025121 | ABM | 500 ng | EUR 394.8 |
MARCO Protein Vector (Human) (pPB-N-His) |
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| PV025122 | ABM | 500 ng | EUR 394.8 |
MARCO Protein Vector (Human) (pPM-C-His) |
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| PV025124 | ABM | 500 ng | EUR 394.8 |
Mouse MARCO ELISA Kit PicoKine® |
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| EK2263 | BosterBio | 96 wells/kit, with removable strips. | EUR 750 |
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Description: Mouse MARCO ELISA Kit PicoKine® (96 Tests). Quantitate Mouse MARCO in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 150 pg/ml. |
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March1 Recombinant Protein (Mouse) |
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| RP149426 | ABM | 100 ug | Ask for price |
March1 Recombinant Protein (Mouse) |
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| RP149429 | ABM | 100 ug | Ask for price |
March1 Recombinant Protein (Mouse) |
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| RP149432 | ABM | 100 ug | Ask for price |
March2 Recombinant Protein (Mouse) |
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| RP149444 | ABM | 100 ug | Ask for price |
March2 Recombinant Protein (Mouse) |
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| RP149447 | ABM | 100 ug | Ask for price |
March3 Recombinant Protein (Mouse) |
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| RP149450 | ABM | 100 ug | Ask for price |
March4 Recombinant Protein (Mouse) |
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| RP149453 | ABM | 100 ug | Ask for price |
March5 Recombinant Protein (Mouse) |
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| RP149456 | ABM | 100 ug | Ask for price |
March5 Recombinant Protein (Mouse) |
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| RP149459 | ABM | 100 ug | Ask for price |
March5 Recombinant Protein (Mouse) |
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| RP149462 | ABM | 100 ug | Ask for price |
March7 Recombinant Protein (Mouse) |
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| RP149468 | ABM | 100 ug | Ask for price |
March8 Recombinant Protein (Mouse) |
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| RP149471 | ABM | 100 ug | Ask for price |
MARCH9 Recombinant Protein (Mouse) |
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| RP149474 | ABM | 100 ug | Ask for price |
MARCKS Recombinant Protein (Mouse) |
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| RP149477 | ABM | 100 ug | Ask for price |
Recombinant Mouse MARCKS-related protein (Marcksl1) |
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| MBS718965-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1120 |
Recombinant Mouse MARCKS-related protein (Marcksl1) |
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| MBS718965-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 700 |
Recombinant Mouse MARCKS-related protein (Marcksl1) |
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| MBS718965-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 870 |
Recombinant Mouse MARCKS-related protein (Marcksl1) |
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| MBS718965-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 840 |
Recombinant Mouse MARCKS-related protein (Marcksl1) |
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| MBS718965-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1020 |
March10 Recombinant Protein (Mouse) |
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| RP149435 | ABM | 100 ug | Ask for price |
March10 Recombinant Protein (Mouse) |
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| RP149438 | ABM | 100 ug | Ask for price |
March11 Recombinant Protein (Mouse) |
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| RP149441 | ABM | 100 ug | Ask for price |
MARCKSL1 Recombinant Protein (Mouse) |
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| RP149480 | ABM | 100 ug | Ask for price |
Marcks (NM_008538) Mouse Recombinant Protein |
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| E45M47407M5 | EnoGene | 20 ug | EUR 1924.54 |
Collectively, our outcomes present that structural restraints current within the protein construction can decide the mechanism of conformational transitions and even easy fashions that accurately seize such structural options can predict their positions. MD simulations of such fashions can thus be used, together with mutational experiments, to manage protein ligand interactions, and modulate ligand binding affinities.
