Crystal structure of a MarR family protein from the psychrophilic bacterium Paenisporosarcina sp. TG-14 in complex with a lipid-like molecule

Crystal structure of a MarR family protein from the psychrophilic bacterium Paenisporosarcina sp. TG-14 in complex with a lipid-like molecule

MarR household proteins regulate the transcription of a number of antibiotic-resistance genes and are broadly present in micro organism and archaea. Lately, a brand new MarR household gene was recognized by genome evaluation of the psychrophilic bacterium Paenisporosarcina sp.
TG-14, which was remoted from sediment-laden basal ice in Antarctica. On this research, the crystal construction of the MarR protein from Paenisporosarcina sp. TG-14 (PaMarR) was decided at 1.6 Å decision. Within the crystal construction, a novel lipid-type compound (palmitic acid) was present in a deep cavity, which was assumed to be an effector-binding web site.
Comparative structural evaluation of homologous MarR household proteins from a mesophile and a hyperthermophile confirmed that the DNA-binding area of PaMarR exhibited comparatively excessive mobility, with a disordered area between the β1 and β2 strands.
As well as, structural comparability with different homologous advanced constructions means that this construction constitutes a conformer reworked by palmitic acid. Biochemical evaluation additionally demonstrated that PaMarR binds to cognate DNA, the place PaMarR is understood to acknowledge two putative binding websites relying on its molar focus, indicating that PaMarR binds to its cognate DNA in a stoichiometric method.
The current research offers structural data on the cold-adaptive MarR protein with an aliphatic compound as its putative effector, extending the scope of MarR household protein analysis.

AlphaFold 2: Why It Works and Its Implications for Understanding the Relationships of Protein Sequence, Construction, and Operate

AlphaFold 2 (AF2) was the star of CASP14, the final biannual construction prediction experiment. Utilizing novel deep studying, AF2 predicted the constructions of many troublesome protein targets at or close to experimental decision. Right here, we current our perspective of why AF2 works and present that it’s a very refined fold recognition algorithm that exploits the completeness of the library of single area PDB constructions.
It has additionally realized native aspect chain packing rearrangements that allow it to refine proteins to excessive decision. The advantages and limitations of its potential to foretell the constructions of many extra proteins at or near atomic element are mentioned.

Forces concerned in freeze-induced egg yolk gelation: Results of assorted bond dissociation reagents on gel properties and protein construction adjustments

Urea, sodium dodecyl sulfate (SDS) and β-mercaptoethanol (2-ME) had been used to observe the roles of hydrogen bonds, hydrophobic interactions and disulfide bonds in frozen egg yolk. Yolk samples had been ready with a denaturant, and the textural traits, turbidity properties, protein patterns and constructions had been analysed.
The outcomes confirmed that SDS or 2-ME addition to egg yolk promoted its turbidity and texture properties, however urea modified the turbidity in another way. SDS-PAGE outcomes confirmed that yolk protein patterns with urea barely diminished the quantity of excessive molecular weight substances, whereas SDS and 2-ME addition elevated the quantity.
ATR-FTIR spectroscopy revealed that the protein secondary constructions modified from ordered constructions to random coils. The feel properties had been correlated with the protein secondary construction, particularly β-sheets and β-turns. Thus, the three bond dissociation reagents induced protein denaturation. Hydrogen bonds had been the vital power affecting frozen egg yolk gelation, adopted by hydrophobic interactions and disulfide bonds.

The First Cytoplasmic Loop within the Core Construction of the ABCC1 (Multidrug Resistance Protein 1; MRP1) Transporter Accommodates A number of Amino Acids Important for Its Expression

ABCC1 (human multidrug resistance protein 1 (hMRP1)) is an ATP-binding cassette transporter which effluxes xeno- and endobiotic natural anions and confers multidrug resistance by means of energetic drug efflux. The 17 transmembrane α-helices of hMRP1 are distributed amongst three membrane spanning domains (MSD0, 1, 2) with MSD1,2 every adopted by a nucleotide binding area to type the 4-domain core construction.
Eight conserved residues within the first cytoplasmic loop (CL4) of MSD1 within the descending α-helix (Gly392, Tyr404, Arg405), the perpendicular coupling helix (Asn412, Arg415, Lys416), and the ascending α-helix (Glu422, Phe434) had been focused for mutagenesis.
Mutants with each alanine and identical cost substitutions of the coupling helix residues had been expressed in HEK cells at wild-type hMRP1 ranges and their transport exercise was solely reasonably compromised. In distinction, mutants of the flanking amino acids (G392I, Y404A, R405A/Ok, E422A/D, and F434Y) had been very poorly expressed though Y404F, E422D, and F434A had been readily expressed and transport competent.
Modeling analyses indicated that Glu422 and Arg615 may type an ion pair that may stabilize transporter expression. Nevertheless, this was not supported by change mutations E422R/R615E which did not enhance hMRP1 ranges. Further constructions accompanied by rigorous biochemical validations are wanted to higher perceive the bonding interactions essential for steady hMRP1 expression.

Construction dictates the mechanism of ligand recognition within the histidine and maltose binding proteins

Two mechanisms, induced match (IF) and conformational choice (CS), have been proposed to elucidate ligand recognition coupled conformational adjustments. The histidine binding protein (HisJ) adopts the CS mechanism, through which a pre-equilibrium is established between the open and the closed states with the ligand binding to the closed state.
Regardless of being structurally just like HisJ, the maltose binding protein (MBP) adopts the IF mechanism, through which the ligand binds the open state and induces a transition to the closed state. To know the molecular determinants of this distinction, we carried out molecular dynamics (MD) simulations of coarse-grained twin construction based mostly fashions.
We discover that intra-protein contacts distinctive to the closed state are ample to advertise the conformational transition in HisJ, indicating a CS-like mechanism. In distinction, further ligand-mimicking contacts are required to “induce” the conformational transition in MBP suggesting an IF-like mechanism.
Crystal structure of a MarR family protein from the psychrophilic bacterium Paenisporosarcina sp. TG-14 in complex with a lipid-like molecule
In settlement with experiments, destabilizing modifications to 2 structural options, the backbone helix (SH) and the balancing interface (BI), current in MBP however absent in HisJ, scale back the necessity for ligand-mimicking contacts indicating that SH and BI act as structural restraints that maintain MBP within the open state.
We introduce an SH like ingredient into HisJ and observe that this will impede the conformational transition rising the significance of ligand-mimicking contacts. Equally, simultaneous mutations to BI and SH in MBP scale back the barrier to conformational transitions considerably and promote a CS-like mechanism.

Mouse Macrophage receptor MARCO, Marco ELISA KIT

ELI-16328m 96 Tests
EUR 1038

Macrophage Receptor MARCO (MARCO) Antibody

20-abx135966
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Macrophage Receptor MARCO (MARCO) Antibody

20-abx322023
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Mouse MARCO shRNA Plasmid

20-abx971431
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Marco ELISA Kit| Mouse Macrophage receptor MARCO ELISA Kit

EF015428 96 Tests
EUR 826.8

MARCO siRNA

20-abx923573
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

MARCO siRNA

20-abx923574
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

MARCO antibody

70R-8509 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal MARCO antibody

MARCO antibody

70R-6455 50 ug
EUR 560.4
Description: Rabbit polyclonal MARCO antibody raised against the N terminal of MARCO

MARCO Antibody

1-CSB-PA880072ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against MARCO. Recognizes MARCO from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

MARCO Antibody

DF15505 100ul
EUR 420

Human Macrophage Receptor MARCO (MARCO) ELISA Kit

20-abx385113
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Macrophage receptor MARCO, MARCO ELISA KIT

ELI-39124h 96 Tests
EUR 988.8

Marco ORF Vector (Mouse) (pORF)

ORF049829 1.0 ug DNA
EUR 607.2

MARCO Protein Vector (Mouse) (pPB-C-His)

PV199314 500 ng
EUR 723.6

MARCO Protein Vector (Mouse) (pPB-N-His)

PV199315 500 ng
EUR 723.6

MARCO Protein Vector (Mouse) (pPM-C-HA)

PV199316 500 ng
EUR 723.6

MARCO Protein Vector (Mouse) (pPM-C-His)

PV199317 500 ng
EUR 723.6

MARCO Rabbit pAb

A10048-100ul 100 ul
EUR 369.6

MARCO Rabbit pAb

A10048-200ul 200 ul
EUR 550.8

MARCO Rabbit pAb

A10048-20ul 20 ul
EUR 219.6

MARCO Rabbit pAb

A10048-50ul 50 ul
EUR 267.6

MARCO Blocking Peptide

33R-3464 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MARCO antibody, catalog no. 70R-8509

MARCO Blocking Peptide

33R-7477 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MARCO antibody, catalog no. 70R-6455

MARCO Polyclonal Antibody

27273-100ul 100ul
EUR 302.4

MARCO Polyclonal Antibody

27273-50ul 50ul
EUR 224.4

MARCO Polyclonal Antibody

ABP59218-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MARCO from Human, Mouse. This MARCO antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human MARCO protein at amino acid sequence of 380-460

MARCO Polyclonal Antibody

ABP59218-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MARCO from Human, Mouse. This MARCO antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human MARCO protein at amino acid sequence of 380-460

MARCO Polyclonal Antibody

ABP59218-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MARCO from Human, Mouse. This MARCO antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human MARCO protein at amino acid sequence of 380-460

MARCO cloning plasmid

CSB-CL880072HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the MARCO gene.

MARCO Polyclonal Antibody

ES9781-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MARCO from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

MARCO Polyclonal Antibody

ES9781-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MARCO from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-MARCO antibody

STJ112088 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

Anti-MARCO antibody

STJ190939 200 µl
EUR 236.4
Description: Unconjugated Rabbit polyclonal to MARCO

Mouse Anti Hamster Marco Monoclonal Antibody

DMABT-47716MH 0.25 mg
EUR 889.2

Marco sgRNA CRISPR Lentivector set (Mouse)

K3658301 3 x 1.0 ug
EUR 406.8

Mouse Macrophage Receptor With Collagenous Structure (MARCO) Protein

20-abx650074
  • EUR 744.00
  • EUR 326.40
  • EUR 2230.80
  • EUR 878.40
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

MARCO Polyclonal Conjugated Antibody

C27273 100ul
EUR 476.4

Human MARCO shRNA Plasmid

20-abx955715
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

MARCO ELISA KIT|Human

EF005227 96 Tests
EUR 826.8

Recombinant Macrophage Receptor With Collagenous Structure (MARCO)

4-RPC614Mu01
  • EUR 528.58
  • EUR 265.20
  • EUR 1652.16
  • EUR 630.72
  • EUR 1141.44
  • EUR 429.60
  • EUR 3950.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Macrophage Receptor With Collagenous Structure expressed in: E.coli

Recombinant Macrophage Receptor With Collagenous Structure (MARCO)

4-RPC614Ra01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Macrophage Receptor With Collagenous Structure expressed in: E.coli

Marco sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3658302 1.0 ug DNA
EUR 184.8

Marco sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3658303 1.0 ug DNA
EUR 184.8

Marco sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3658304 1.0 ug DNA
EUR 184.8

Marco ORF Vector (Rat) (pORF)

ORF070301 1.0 ug DNA
EUR 607.2

MARCO ORF Vector (Human) (pORF)

ORF006281 1.0 ug DNA
EUR 114

MARCO Protein Vector (Human) (pPB-C-His)

PV025121 500 ng
EUR 394.8

MARCO Protein Vector (Human) (pPB-N-His)

PV025122 500 ng
EUR 394.8

MARCO Protein Vector (Human) (pPM-C-HA)

PV025123 500 ng
EUR 394.8

MARCO Protein Vector (Human) (pPM-C-His)

PV025124 500 ng
EUR 394.8

MARCO Protein Vector (Rat) (pPB-C-His)

PV281202 500 ng
EUR 723.6

MARCO Protein Vector (Rat) (pPB-N-His)

PV281203 500 ng
EUR 723.6

MARCO Protein Vector (Rat) (pPM-C-HA)

PV281204 500 ng
EUR 723.6

MARCO Protein Vector (Rat) (pPM-C-His)

PV281205 500 ng
EUR 723.6

Rat Macrophage Receptor With Collagenous Structure (MARCO) Protein

20-abx650075
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse)

4-PAC614Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO)

Marco sgRNA CRISPR Lentivector set (Rat)

K6667901 3 x 1.0 ug
EUR 406.8

MARCO sgRNA CRISPR Lentivector set (Human)

K1270701 3 x 1.0 ug
EUR 406.8

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), APC

4-PAC614Mu01-APC
  • EUR 421.20
  • EUR 4038.00
  • EUR 1122.00
  • EUR 538.80
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with APC.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), Biotinylated

4-PAC614Mu01-Biotin
  • EUR 379.20
  • EUR 3031.20
  • EUR 892.80
  • EUR 464.40
  • EUR 265.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with Biotin.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), Cy3

4-PAC614Mu01-Cy3
  • EUR 512.40
  • EUR 5334.00
  • EUR 1446.00
  • EUR 668.40
  • EUR 304.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with Cy3.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), FITC

4-PAC614Mu01-FITC
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with FITC.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), HRP

4-PAC614Mu01-HRP
  • EUR 385.20
  • EUR 3519.60
  • EUR 992.40
  • EUR 486.00
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with HRP.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), PE

4-PAC614Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with PE.

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K3658305 3 x 1.0 ug
EUR 451.2

Macrophage Receptor With Collagenous Structure (MARCO) Antibody

20-abx131562
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Macrophage Receptor With Collagenous Structure (MARCO) Antibody

20-abx131563
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Marco sgRNA CRISPR Lentivector (Rat) (Target 1)

K6667902 1.0 ug DNA
EUR 184.8

Marco sgRNA CRISPR Lentivector (Rat) (Target 2)

K6667903 1.0 ug DNA
EUR 184.8

Marco sgRNA CRISPR Lentivector (Rat) (Target 3)

K6667904 1.0 ug DNA
EUR 184.8

MARCO sgRNA CRISPR Lentivector (Human) (Target 1)

K1270702 1.0 ug DNA
EUR 184.8

MARCO sgRNA CRISPR Lentivector (Human) (Target 2)

K1270703 1.0 ug DNA
EUR 184.8

MARCO sgRNA CRISPR Lentivector (Human) (Target 3)

K1270704 1.0 ug DNA
EUR 184.8

MARCO 3'UTR GFP Stable Cell Line

TU063026 1.0 ml
EUR 1672.8

Marco 3'UTR GFP Stable Cell Line

TU262886 1.0 ml Ask for price

Marco 3'UTR Luciferase Stable Cell Line

TU112920 1.0 ml Ask for price

Marco 3'UTR GFP Stable Cell Line

TU162920 1.0 ml Ask for price

MARCO 3'UTR Luciferase Stable Cell Line

TU013026 1.0 ml
EUR 1672.8

Marco 3'UTR Luciferase Stable Cell Line

TU212886 1.0 ml Ask for price

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Mouse), APC-Cy7

4-PAC614Mu01-APC-Cy7
  • EUR 699.60
  • EUR 7932.00
  • EUR 2100.00
  • EUR 933.60
  • EUR 388.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with APC-Cy7.

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K3658306 1.0 ug DNA
EUR 200.4

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K3658307 1.0 ug DNA
EUR 200.4

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K3658308 1.0 ug DNA
EUR 200.4

MARCO Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV622369 1.0 ug DNA
EUR 818.4

MARCO Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV622373 1.0 ug DNA
EUR 818.4

MARCO Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV622374 1.0 ug DNA
EUR 818.4

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat)

4-PAC614Ra01
  • EUR 310.80
  • EUR 3249.60
  • EUR 804.00
  • EUR 393.60
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO)

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6667905 3 x 1.0 ug
EUR 451.2

MARCO sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K1270705 3 x 1.0 ug
EUR 451.2

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), APC

4-PAC614Ra01-APC
  • EUR 436.80
  • EUR 4254.00
  • EUR 1176.00
  • EUR 560.40
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with APC.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), Biotinylated

4-PAC614Ra01-Biotin
  • EUR 390.00
  • EUR 3189.60
  • EUR 932.40
  • EUR 480.00
  • EUR 270.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with Biotin.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), Cy3

4-PAC614Ra01-Cy3
  • EUR 532.80
  • EUR 5622.00
  • EUR 1518.00
  • EUR 697.20
  • EUR 313.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with Cy3.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), FITC

4-PAC614Ra01-FITC
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with FITC.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), HRP

4-PAC614Ra01-HRP
  • EUR 398.40
  • EUR 3706.80
  • EUR 1039.20
  • EUR 505.20
  • EUR 255.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with HRP.

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), PE

4-PAC614Ra01-PE
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with PE.

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6667906 1.0 ug DNA
EUR 200.4

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6667907 1.0 ug DNA
EUR 200.4

Marco sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6667908 1.0 ug DNA
EUR 200.4

MARCO Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV622370 1.0 ug DNA
EUR 818.4

MARCO Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV622371 1.0 ug DNA
EUR 888

MARCO Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV622372 1.0 ug DNA
EUR 888

MARCO sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K1270706 1.0 ug DNA
EUR 200.4

MARCO sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K1270707 1.0 ug DNA
EUR 200.4

MARCO sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K1270708 1.0 ug DNA
EUR 200.4

Macrophage Receptor With Collagenous Structure (MARCO) Polyclonal Antibody (Human, Rat), APC-Cy7

4-PAC614Ra01-APC-Cy7
  • EUR 729.60
  • EUR 8364.00
  • EUR 2208.00
  • EUR 976.80
  • EUR 402.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human, Rat Macrophage Receptor With Collagenous Structure (MARCO). This antibody is labeled with APC-Cy7.

Recombinant Mouse C1ql1 Protein

CTP-018 100ug Ask for price
Description: A recombinant mouse C1ql1 protein with a N-terminal tag or C-terminal tag expressed inE. Coli, yeast, insect, or mammalian cell.

Recombinant Mouse C1s1 Protein

CTP-031 100ug Ask for price
Description: A recombinant mouse C1s1 protein with a N-terminal tag or C-terminal tag expressed in E. coli, yeast, insect, or mammalian cells.

Recombinant Mouse C1s2 Protein

CTP-032 100ug Ask for price
Description: A recombinant mouse C1s2 protein with a N-terminal tag or C-terminal tag expressed in E. coli, yeast, insect, or mammalian cells.

Recombinant Mouse C4bp Protein

CTP-063 100ug Ask for price
Description: A recombinant mouse C4bp protein with a N-terminal tag or C-terminal tag expressed in E. Coli, yeast, insect, or mammalian cell.

Recombinant Mouse C1qtnf1 Protein

CTP-153 100ug Ask for price
Description: A recombinant mouse C1qtnf1 protein with a N-terminal tag or C-terminal tag expressed in E. Coli, yeast, insect, or mammalian cell.

Recombinant Mouse C1QTNF4 Protein

CTP-167 100ug Ask for price
Description: A recombinant mouse C1QTNF4 protein with a N-terminal tag or C-terminal tag expressed in E. Coli, yeast, insect, or mammalian cell.

Recombinant Mouse C1qtnf7 Protein

CTP-180 100ug Ask for price
Description: A recombinant mouse C1qtnf7 protein with a N-terminal tag or C-terminal tag expressed in E. Coli, yeast, insect, or mammalian cell.

Recombinant Mouse C1qtnf9 Protein

CTP-188 100ug Ask for price
Description: A recombinant mouse C1qtnf9 protein with a N-terminal tag or C-terminal tag expressed in E. Coli, yeast, insect, or mammalian cell.

Follistatin, mouse recombinant protein

P1055-.02 20 µg
EUR 375.6
Description: Follistatin is a high-affinity activin-binding protein produced in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Follistatin acts as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH.

Follistatin, mouse recombinant protein

P1055-.1 100 µg
EUR 1279.2
Description: Follistatin is a high-affinity activin-binding protein produced in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Follistatin acts as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH.

Follistatin, mouse recombinant protein

P1055-1 1 mg
EUR 8737.2
Description: Follistatin is a high-affinity activin-binding protein produced in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Follistatin acts as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH.

Visfatin, mouse recombinant protein

P1117-.01 10 µg
EUR 243.6
Description: Visfatin also known as Pre-B cell colony enhancing factor, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF. Visfatin is a novel adipocytokine produced by visceral fat.

Visfatin, mouse recombinant protein

P1117-.05 50 µg
EUR 634.8
Description: Visfatin also known as Pre-B cell colony enhancing factor, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF. Visfatin is a novel adipocytokine produced by visceral fat.

Visfatin, mouse recombinant protein

P1117-1 1 mg
EUR 4987.2
Description: Visfatin also known as Pre-B cell colony enhancing factor, Nicotinamide phosphoribosyltransferase, Pre-B-cell colony-enhancing factor 1 homolog, NAmPRTase, Nampt, PBEF. Visfatin is a novel adipocytokine produced by visceral fat.

CD93 Mouse Recombinant Protein

PROTO89103 Regular: 10ug
EUR 380.4
Description: CD93 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 558 amino acids (23-572a.a.) and having a molecular mass of 60.1kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).;CD93 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Renin Mouse Recombinant Protein

PROTP06281 Regular: 5ug
EUR 380.4
Description: REN produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 387 amino acids (22-402 a.a.) andhaving a molecular mass of 42.5kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).REN is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

Prolactin Mouse Recombinant Protein

PROTP06879 Regular: 50ug
EUR 380.4
Description: Prolactin Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.5 kDa. ;The Prolactin is purified by proprietary chromatographic techniques.

CD14 Mouse Recombinant Protein

PROTP10810 Regular: 5ug
EUR 574.8
Description: The CD14 is produced from mouse CD14 transfected CHO-cells in serum free medium. Before transfection the complete mouse CD14-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR). The recombinant mouse CD-14 was purified by His-tag and controlled by SDS page.;The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wildtype CD14 is the 50 kDa protein.

Midkine Mouse Recombinant Protein

PROTP12025 Regular: 20ug
EUR 380.4
Description: Midkine Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 120 amino acids and having a molecular mass of 13.3kDa.;The Midkine Mouse is purified by proprietary chromatographic techniques.

GAPDH Mouse Recombinant Protein

PROTP16858 Regular: 20ug
EUR 380.4
Description: GAPDH Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 356 amino acids (1-333a.a.) and having a molecular mass of 38.2kDa.;GAPDH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Leptin Mouse Recombinant Protein

PROTP41160 Regular: 1mg
EUR 380.4
Description: Leptin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16.2 kDa.;The Leptin is purified by proprietary chromatographic techniques.

Procalcitonin Mouse Recombinant Protein

PROTP70160 Regular: 10ug
EUR 380.4
Description: Procalcitonin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Val26-Ser136) containing 121 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 13.6kDa.

Noggin Mouse Recombinant Protein

PROTP97466 Regular: 20ug
EUR 380.4
Description: Noggin Mouse Recombinant produced in E.Coli is a non-glycosylated, disulfide-linked protein consisting of two 206 amino acid polypeptide chains, having a total molecular mass of approximately 46.4 kDa (each chain 23.2 kDa).

CD80 Mouse Recombinant Protein

PROTQ00609 Regular: 10ug
EUR 380.4
Description: CD80 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 216 amino acids (37-246 a.a.) and having a molecular mass of 24.7kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions). CD80 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Bax Mouse Recombinant Protein

PROTQ07813 Regular: 10ug
EUR 380.4
Description: Bax Mouse Recombinant amino acid 38-171 produced in E.Coli is a single, non-glycosylated polypeptide chain. The Mouse Bax is purified by proprietary chromatographic techniques.

CD36 Mouse Recombinant Protein

PROTQ08857 Regular: 10ug
EUR 380.4
Description: CD36 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 419 amino acids (30-439a.a.) and having a molecular mass of 47.4kDa (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).;CD36 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

CD55 Mouse Recombinant Protein

PROTQ61475 Regular: 10ug
EUR 380.4
Description: CD55 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 336 amino acids (35-362 a.a.) andhaving a molecular mass of 36.8kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).

Endoglin Mouse Recombinant Protein

PROTQ63961 Regular: 10ug
EUR 380.4
Description: CD105 Mouse Recombinant extracellular domain produced in baculovirus is a homodimeric, glycosylated, Polypeptide containing 581 amino acids and having a molecular mass of 61 kDa but as a result of glycosylation, migrates at 75-85 kDa under reducing conditions in SDS-PAGE. Based on N-terminal sequence_x000D_ analysis, the primary structure of recombinant mature Endoglin starts at Glu 26._x000D_ The CD105 is fused to a C-terminal His-tag (6xHis) and purified by proprietary chromatographic techniques.

CXCL16 Mouse Recombinant Protein

PROTQ8BSU2 Regular: 25ug
EUR 380.4
Description: CXCL16 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 9.9kDa. ;The CXCL16 is purified by proprietary chromatographic techniques.

Visfatin Mouse Recombinant Protein

PROTQ99KQ4 Regular: 25ug
EUR 380.4
Description: Visfatin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (aa 1-491) containing a 20 aa His tag and having 511 amino acids. The total molecular mass is 57kDa. The Visfatin is purified by proprietary chromatographic techniques.

APRIL Mouse Recombinant Protein

PROTQ9D777 Regular: 20ug
EUR 380.4
Description: APRIL Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of 16.4 kDa. The APRIL is purified by proprietary chromatographic techniques.

CD274 Mouse Recombinant Protein

PROTQ9EP73 Regular: 20ug
EUR 380.4
Description: CD274 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 246 amino acids (19-239 a.a) and having a molecular mass of 27.6kDa (Molecular size on SDS-PAGE will appear higher).;CD274 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Resistin Mouse Recombinant Protein

PROTQ9HD89-3 Regular: 25ug
EUR 380.4
Description: Resistin Mouse Recombinant produced in E.Coli is a non glycosylated, homodimeric polypeptide chain containing 2 x 95 amino acids and having a total molecular mass of 20.6kDa. The Resistin is purified by proprietary chromatographic techniques.

Mouse CXCL12 Recombinant Protein

R00053 5ug/vial
EUR 310.8
Description: The C-X-C motif chemokine CXCL12 binds to one single chemokine receptor, CXCR4, to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 and its receptor CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis. Mouse CXCL12 Recombinant Protein is purified CXCL12 produced in yeast.
Collectively, our outcomes present that structural restraints current within the protein construction can decide the mechanism of conformational transitions and even easy fashions that accurately seize such structural options can predict their positions. MD simulations of such fashions can thus be used, together with mutational experiments, to manage protein ligand interactions, and modulate ligand binding affinities.

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